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Health & Medicine Reference Researchers have identified five subtypes of breast cancer by their gene expression patterns. The subtypes – basal, HER2-positive, luminal A and B, and normal-like – vary in their natural history and response to therapy. CellSearch is an antibody-based test, approved by the U.S. Food and Drug Administration, to detect circulating breast cancer cells ...

Health & Medicine Reference The protein cyclophilin B affects cell division, motility, and death, all of which are altered in cancerous cells. To explore the role of cyclophilin B-mediated gene regulation in breast cancer, Dr. Clevenger and colleagues inhibited cyclophilin B expression in breast cancer cells. They found that absence of cyclophilin B impacted 27 different protein ...

Health & Medicine Reference Because DNA damage is associated with cancer development, researchers hypothesized that genes required for DNA repair may influence risk of cancer. Initial reports supported the idea. A comprehensive review of the data has not been available previously. In the current study, John P. Ioannidis, M.D., of the University of Ioannina School of Medicine ...

Health & Medicine Reference Epidemiological studies have suggested that people whose diets are high in fruits and vegetables, and thus antioxidants, may have a lower risk of cancer. Results from randomized trials that address the issue, however, have been inconsistent and have rarely supported that observation. In the current study, Jennifer Lin, Ph.D., of the Brigham and ...

Health & Medicine Mind & Brain Reference A new paper, authored by Caitlin Ryan, PhD, Director of the Family Acceptance Project and her team at the César E. Chávez Institute at San Francisco State University, shows that negative parental behaviors toward LGB children dramatically compromises their health. The discovery has far reaching implications for changing how ...